The Carter lab develops new optical microscopes and applies them to important biological problems.

 

Advanced Microscopy Development Unit (AMDU)

We are developing a number of projects based on our new Warwick Open Source Microscope (WOSM) platform. The WOSM will be an excellent base for the development of techniques such as TIRF, super-resolution imaging and live cell imaging where very low drift and minimal light loss are essential characteristics. The WOSM will also deliver the exceptional stability and efficiency required for single molecule recordings.

 

Single molecule imaging

A major interest is the use of laser tweezers (optical trapping) to measure the steps and forces produced by single kinesin molecules as they walk along microtubules. Current trapping work is focusing on the mechanochemistry of kinesin backsteps.

Nick Carter

Selected Publications

 

Carter N.J., Cross R.A.. (2005)
Mechanics of the kinesin step.
Nature 435:308-12.

 

Carter N.J., Cross R.A.. (2006)
Kinesin's moonwalk.
Curr Opin Cell Biol., 18:61-7.

 


wosm

soon.....
Wosmic.org the WOSM website

lab members & projects

JamesJames McLachlan | MOAC PhD student | funded by EPSRC

James has just begun his PhD looking into single molecule mechanochemistry of several kinesins from fission yeast and modelling their behaviour.

funding sources

 

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