research

 

Our research in plain english

We are working on two things that cells do: how they divide and how they 'eat' things from the outside. Dividing and eating are as important for cells as for people! So any problems with these jobs can lead to disease. This is why we are trying to understand these jobs, so that we can think of new ways to treat human diseases.


Steve runs a website called quantixed. On there, we describe the papers that we publish in simple terms that can be understood by non-specialists. For example, see this post. These posts are tagged with outreach. Feel free to take a look.


Our work on mitosis

spindle

When a cell divides, each of the two new cells must get one copy of the genome each. The cell makes a machine called the mitotic spindle to share the chromosomes (genome) equally between the two cells. This is a very important task: cells that have too few or too many chromosomes can become cancerous. Our lab is trying to figure out how the mitotic spindle does this so efficiently. There are certain fibres within the spindle that pull chromosomes around the cell to share them out. These fibres are made up of many smaller tubules that are held together by "bridges". We are using powerful microscopes to study these bridges and find out what they are made of.

So far, we have found that some of these bridges are made by four different proteins working together. Three of these proteins are overexpressed in cancer. This means that in patients with these tumours, the cancer cells are making too much of these proteins. We are figuring out how this might cause the tumour, or how it might make the cancer get worse.

We also working on what happens when cells share the chromosomes incorrectly. Using a microscope that allows us to watch chromosomes inside dividing cells, we can see mistakes in sharing chromosomes. Sometimes, this can lead to micronuclei (very small nuclei) forming in the cell after division, and these are linked to cancer.


Our work on membrane trafficking

endo

Cells can be thought of as islands – they are closed to the outside world because they have a plasma membrane that doesn't let anything through. However, cells have evolved tiny portals for things to enter in a highly controlled way. These portals are working all the time. They use a protein called clathrin together with many other proteins in order to work. We are trying to understand how these proteins come together to do this.

Inside the cell is a busy world with vesicles moving here and there. These vesicles are making sure that important proteins get to the right place at the right time to keep the cell working normally. We have found a new type of vesicle, which is very small (nanoscale). Our lab is trying to figure out how these vesicles are formed and moved around.