
Dancing partnersWe reveal the kinetochore components involved in corrdinating microtubule dynamics
>> Nature Cell Biology, in press
>> in plain english | e-print
along with the Danuser, Swedlow and Meraldi labs we automatically track sister kinetochores in metaphase
>> Journal of Cell Biology, 188 665-79 2010
>>in plain english | e-print
Miho shows definitively that Mal3 inhibits shrinkage and accelerates rescue - but does not affect catastrophe.
>> J. Biol. Chem., 23 29246-50 2009
>> in plain english | e-print
Marcus showed that kinesin-14 actively sorts microtubules into parallel bundles.
>> Nature Cell Biology 11 724-30, 2009
>> in plain english | e-print

How the CMCB came to beJan 2010 | The idea for the CMCB had a lengthy gestation, but then was born quite suddenly one rainy day in March last year, when we learned > more here
The new CMCB building3 Mar 2010 | The Wolfson Foundation have agreed to provide £1 million towards the construction of the new WMS Centre for Mechanochemical Cell Biology (CMCB) on the University's Gibbet Hill site. The contribution from the Wolfson Foundation brings the total build budget to £6.4 million, with £3.4 million > more here

The AMDU has two defining roles, to develop advanced microscope technology and to provide access to advanced microscope technology. >> more here
[Book a microscope] (coming soon)

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>> Mar 10 - Seminar Masanori Mishima (Gurdon Institute) 14:00 TM1 T0.08
Clustering of the centralspindlin Kinesin-6/RhoGAP complex regulated by Aurora B and 14-3-3 is essential for its sharp midzone accumulation during cytokinesis.
Cytokinesis in animal cells requires post-metaphase microtubule bundle structures such as the central spindle and midbody. Centralspindlin, a heterotetrameric complex consisting of Kinesin-6 (MKLP1/Pavarotti/ZEN-4) and RhoGAP (MgcRacGAP/RacGAP50C/CYK-4) subunits, is essential for the formation of these structures. Centralspindlin also plays a critical role in recruitment of various cytokinesis regulators to the site of division. However, the mechanism of sudden accumulation of centralspindlin to the centre of interpolar microtubule bundles has been unclear. We have discovered that higher-order clustering of centralspindlin is critical for its processive motility in vitro and for midbody formation in vivo. Furthermore, we have found that the clustering is coordinately regulated by Aurora B kinase and 14-3-3 protein. Based on these findings, we propose a positive feedback loop of centralspindlin clustering and microtubule organisation that may underlie its distinctive localisation during cytokinesis.
>> Mar 3 - MOAC projects fair

>> Mar 1 - Spring is here. Plastic boxes cleared away, move to Warwick complete; some of us at least are doing experiments (above).
>> Coming shortly: Collaborators pages; Warwick bioimaging portal; science outreach page CMCBeebies; plain english versions of our papers.


