mechanochemistry

 


The mission of the Centre for Mechanochemical Cell Biology at Warwick is to discover the molecular and cellular mechanisms driving active self-organisation in living systems. Our unique Centre was launched in 2010 and has grown meanwhile from 3 to 8 PIs, including three Wellcome Senior Investigators. The centre is housed in a purpose-designed building that was opened by Sir Paul Nurse in 2012. An extension is under construction and will open in 2016.

 

Alp14Faster, stronger

A Cross lab team show that the Alp7/14 tip-tracker both accelerates microtubule growth and stabilises microtubule tips.
>> Nature Scientific Reports (2016) | [Open Access]

meiosismeiotic kinetochores

Jess Patel reveals how kinetochores operate differently during meiosis in humans and how this may explain chromosome errors as maternal age increases.
>> Biology Open (2015) | open access

inferthe force awakens

Burroughs and McAinsh use mathematical modelling to infer the forces controlling kinetochore motion.
>> PLOS Computational Biology (2015) | open access

superSuper Track

Burroughs and McAinsh reveal how a force-sensitive molecular clock controls direction of kinetochore movements - a key requirement for chromosome positioning.
>> eLife (2015) | link

bundleWalking home

The Mishima lab shows that cells link PRC1 to centralspindlin to create a motorised crosslinker that actively maintains the integrity of the central spindle.
>> Nature Communications (2015) | link

bundleThe Mesh

Discovery of a meshwork of inter-microtubule connectors in kinetochore fibres of the mitotic spindle by the Royle lab.

>> eLife (2015) | link | blog